| Autor: |
Krasikova RN; Institute of Human Brain, Russian Academy of Science, 9, Pavlov strasse, 197376, St.-Petersburg, Russia., Zaitsev VV, Ametamey SM, Kuznetsova OF, Fedorova OS, Mosevich IK, Belokon YN, Vyskocil S, Shatik SV, Nader M, Schubiger PA |
| Jazyk: |
angličtina |
| Zdroj: |
Nuclear medicine and biology [Nucl Med Biol] 2004 Jul; Vol. 31 (5), pp. 597-603. |
| DOI: |
10.1016/j.nucmedbio.2003.12.010 |
| Abstrakt: |
We describe a new method for the asymmetric synthesis of [(18)F]fluorinated aromatic alpha-amino acids (FAA) under phase transfer conditions using achiral glycine derivative NiPBPGly and (S)-NOBIN as a novel substrate/catalyst pair. The key alkylation step proceeds under mild conditions. Substituted [(18)F]fluorobenzylbromides were prepared using nucleophilic [(18)F]fluoride and were used as alkylation agents. Two important FAA, 2-[(18)F]fluoro-L-tyrosine (2-FTYR) and 6-[(18)F]fluoro-L-3,4-dihydroxyphenylalanine (6-FDOPA), were synthesized with an ee of 92 and 96%, respectively. The total synthesis time was 110-120 min and radiochemical yields (d.c.) were 25+/-6% for 2-FTYR and 16+/-5% for 6-FDOPA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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