| Autor: |
Sung YJ; Department of Anatomy and Cell Biology Columbia University, 630 West 168th Street, New York, NY 10032, USA., Weiler IJ, Greenough WT, Denman RB |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research. Molecular brain research [Brain Res Mol Brain Res] 2004 Jul 05; Vol. 126 (1), pp. 81-7. |
| DOI: |
10.1016/j.molbrainres.2004.03.013 |
| Abstrakt: |
Differential display was used to identify synapse-enriched mRNAs. Of 15 mRNAs initially identified, all were found in multiple synaptoneurosome preparations; 58% were subsequently shown to be enriched in all the preparations by Northern blotting and semiquantitative RT-PCR. RNAs involved in signal transduction, vesicle trafficking, lipid modification and cell shape and remodeling were among these messages. Tip60a mRNA, recently found to associate with the fragile X mental retardation protein, was also identified. These data demonstrate the diversity of the local message pool at synapses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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