| Autor: |
Sbardella G; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy., Mai A, Artico M, Setzu MG, Poni G, La Colla P |
| Jazyk: |
angličtina |
| Zdroj: |
Farmaco (Societa chimica italiana : 1989) [Farmaco] 2004 Jun; Vol. 59 (6), pp. 463-71. |
| DOI: |
10.1016/j.farmac.2004.01.014 |
| Abstrakt: |
Pursuing our searches on quinolonecarboxylic acids we used a simple three-step one pot procedure to synthesize novel 1,7-disubstituted-6-nitroquinolones. The new derivatives were tested against Mycobacterium tuberculosis and Mycobacterium avium complex (MAC) as well as against both gram-positive and gram-negative bacteria. In vitro assays showed some derivatives were endowed with good inhibiting activities against tested mycobacteria. Some derivatives were also found more potent than ciprofloxacin and ofloxacin (used as reference drugs) against gram-positive bacteria. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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