| Autor: |
Kitchen SG; Department of Medicine and Microbiology, David Geffen School of Medicine, University of California, 11-934 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA., Jones NR, LaForge S, Whitmire JK, Vu BA, Galic Z, Brooks DG, Brown SJ, Kitchen CM, Zack JA |
| Jazyk: |
angličtina |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2004 Jun 08; Vol. 101 (23), pp. 8727-32. Date of Electronic Publication: 2004 Jun 01. |
| DOI: |
10.1073/pnas.0401500101 |
| Abstrakt: |
Costimulation of purified CD8(+) T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4 molecule plays a direct role in CD8(+) T cell function by modulating expression of IFN-gamma and Fas ligand, two important CD8(+) T cell effector molecules. CD4 expression also allows infection of CD8 cells by HIV, which results in down-regulation of the CD4 molecule and impairs the induction of IFN-gamma, Fas ligand, and the cytotoxic responses of activated CD8(+) T cells. Thus, the CD4 molecule plays a direct role in CD8 T cell function, and infection of these cells by HIV provides an additional reservoir for the virus and also may contribute to the immunodeficiency seen in HIV disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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