MR-trackable intramyocardial injection catheter.

Autor: Karmarkar PV; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA. pkarmar@mri.jhu.edu, Kraitchman DL, Izbudak I, Hofmann LV, Amado LC, Fritzges D, Young R, Pittenger M, Bulte JW, Atalar E
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2004 Jun; Vol. 51 (6), pp. 1163-72.
DOI: 10.1002/mrm.20086
Abstrakt: There is growing interest in delivering cellular agents to infarcted myocardium to prevent postinfarction left ventricular remodeling. MRI can be effectively used to differentiate infarcted from healthy myocardium. MR-guided delivery of cellular agents/therapeutics is appealing because the therapeutics can be precisely targeted to the desired location within the infarct. In this study, a steerable intramyocardial injection catheter that can be actively tracked under MRI was developed and tested. The components of the catheter were arranged to form a loopless RF antenna receiver coil that enabled active tracking. Feasibility studies were performed in canine and porcine myocardial infarction models. Myocardial delayed-enhancement (MDE) imaging identified the infarcted myocardium, and real-time MRI was used to guide left ventricular catheterization from a carotid artery approach. The distal 35 cm of the catheter was seen under MRI with a bright signal at the distal tip of the catheter. The catheter was steered into position, the distal tip was apposed against the infarct, the needle was advanced, and a bolus of MR contrast agent and tissue marker dye was injected intramyocardially, as confirmed by imaging and postmortem histology. A pilot study involving intramyocardial delivery of magnetically labeled stem cells demonstrated the utility of the active injection catheter system.
(Copyright 2004 Wiley-Liss, Inc.)
Databáze: MEDLINE
Externí odkaz: