| Autor: |
Wicks J; Queensland Institute of Medical Research, Brisbane, Australia. jackiW@qimr.edu.au, Treloar SA, Martin NG |
| Jazyk: |
angličtina |
| Zdroj: |
Twin research : the official journal of the International Society for Twin Studies [Twin Res] 2004 Apr; Vol. 7 (2), pp. 211-6. |
| DOI: |
10.1375/136905204323016195 |
| Abstrakt: |
The aim of this study was to determine whether identity-by-descent (IBD) information for affected sib pairs (ASPs) can be used to select a sample of cases for a genetic case-control study which will provide more power for detecting association with loci in a known linkage region. By modeling the expected frequency of the disease allele in ASPs showing IBD sharing of 0, 1, or 2 alleles, and considering additive, recessive, and dominant disease models, we show that cases selected from IBD 2 families are best for this purpose, followed by those selected from IBD 1 families; least useful are cases selected from IBD 0 families. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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