Cutaneous ulcers: An unusual manifestation of inherited thrombophilia.
| Autor: | Mavragani CP; Department of Pathophysiology, School of Medicine, National University of Athens, Greece., Pikazis D, Aroni K, Paikos S, Voulgarelis M |
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| Jazyk: | angličtina |
| Zdroj: | American journal of hematology [Am J Hematol] 2004 Jun; Vol. 76 (2), pp. 139-42. |
| DOI: | 10.1002/ajh.20077 |
| Abstrakt: | We report two cases with cutaneous lesions found to be associated with factor V Leiden mutation and low S protein levels. At the time of presentation, no other symptoms were reported. Histopathology of both lesions revealed the presence of widespread intravascular thrombi. The therapeutic response to oral anticoagulants in the first case was dramatic, leading to complete healing of the lesions. Inherited causes of thrombophilia manifested as cutaneous lesions, although rare, should be considered in the differential diagnosis of occlusive vasculopathy. (Copyright 2004 Wiley-Liss, Inc.) |
| Databáze: | MEDLINE |
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