Asperger Syndrome, obsessive-compulsive disorder, and major depression in a patient with 45,X/46,XY mosaicism.
| Autor: | Fontenelle LF; Anxiety and Depression Research Program, Institute of Psychiatry of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. leofontenelle@hotmail.com, Mendlowicz MV, Bezerra de Menezes G, dos Santos Martins RR, Versiani M |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Psychopathology [Psychopathology] 2004 May-Jun; Vol. 37 (3), pp. 105-9. Date of Electronic Publication: 2004 May 18. |
| DOI: | 10.1159/000078608 |
| Abstrakt: | Background: Although previous reports have described the association of autism, mental retardation, and schizophrenia with a missing Y chromosome, we are not aware of any case showing an association between this particular chromosomal abnormality and Asperger syndrome. Method: We report the case of a male patient with a combination of Asperger syndrome, obsessive-compulsive disorder and 45,X/46,XY mosaicism. During the follow-up, this individual has also developed a severe episode of major depression, which was successfully treated with electroconvulsive therapy. Results: To the best of our knowledge, this is the first case in which a 45,X/46,XY mosaicism was described in association with Asperger syndrome, either alone or associated with other psychiatric disorders. Diagnostic and therapeutic aspects of this unique case are presented and discussed. Conclusions: Our findings suggest that a missing Y chromosome may play an etiological role in some cases of Asperger syndrome. (Copyright 2004 S. Karger AG, Basel) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|