| Autor: |
Cox FE; Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. frank.cox@lshtm.ac.uk |
| Jazyk: |
angličtina |
| Zdroj: |
Infectious disease clinics of North America [Infect Dis Clin North Am] 2004 Jun; Vol. 18 (2), pp. 231-45. |
| DOI: |
10.1016/j.idc.2004.01.004 |
| Abstrakt: |
Infections with subspecies of the protozoan parasite Trypanosoma brucei cause important wasting diseases in Africa (nagana in cattle and sleeping sickness in humans). These diseases were little known until the end of the nineteenth century when serious epidemics of nagana were reported and raised concern among the colonial powers. The early history of sleeping sickness revolves around the discovery of the causative organism, its mode of transmission,and its life cycle in the tsetse fly. The history continues into the twentieth century with the discovery of how the parasites evade the immune response, frustrating the development of a vaccine; the failure to develop cheap and effective drugs; and the development of alternative approaches to control the tsetse fly vector. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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