[Synthesis and immunomodulating activity of new diglycopeptides of of glycyrrhizinic acid and it's 30-methyl ester].

Autor: Kondratenko RM; Bashkortostan State Medical University, Ufa, Bashkortostan, 450074 Russia., Baltina LA, Vasil'eva EV, Nasyrov KhM, Kireeva RM, Baschenko NZh, Fridman SM, Baltina LA, Tolstikov GA
Jazyk: ruština
Zdroj: Bioorganicheskaia khimiia [Bioorg Khim] 2004 Mar-Apr; Vol. 30 (2), pp. 168-73.
DOI: 10.1023/b:rubi.0000023100.52170.6b
Abstrakt: New amino acid derivatives of glycyrrhizic acid and its methyl ester were selectively synthesized using active N-succinimide esters. The compounds with residues of glycine ethyl ester and alanine methyl and butyl esters increased the level of agglutinins and hemolysins in blood serum of mice two- to threefold in comparison with the control upon parenteral administration at a dose of 2 mg/kg for 14 days. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.
Databáze: MEDLINE