| Autor: |
Schutte B; Department of Molecular Cell Biology, Research Institute for Growth and Development (GROW), University of Maastricht, Maastricht, The Netherlands., Harmsa M, Costongs G, Henfling M, Ummelen M, Dignef W, Ramaekers F |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of oncology [Int J Oncol] 2004 Jun; Vol. 24 (6), pp. 1357-67. |
| Abstrakt: |
The effects of Noclosan and Loxat, extracts from the potato tuber, on cancer cell lines and human endothelial cells in culture were examined with respect to cell cycle inhibition and apoptosis induction. Both components effect the cell cycle of the cancer cell lines, most likely by inhibition of the M to G1-phase transition. Furthermore, both compounds very effectively induced apoptosis in a dose-dependent manner. Strikingly, combination of both compounds revealed a synergistic effect, that can be explained by the observation that induction of apoptosis occurs through both the mitochondrial and the non-mitochondrial route. Preliminary studies suggest that the components affect the SAPK/JNK cell signaling pathway. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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