Serum TNF-alpha in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene.
Autor: | Elias AN; Department of Medicine, Division of Endocrinology and Metabolism, University of California, Irvine Medical Center, 101 The City Drive, Orange, California 92868, USA. anelias@uci.edu, Nanda VS, Pandian R |
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Jazyk: | angličtina |
Zdroj: | BMC dermatology [BMC Dermatol] 2004 Apr 30; Vol. 4, pp. 4. Date of Electronic Publication: 2004 Apr 30. |
DOI: | 10.1186/1471-5945-4-4 |
Abstrakt: | Background: Tumor necrosis factor-alpha (TNF-alpha) and its receptors play important roles in the development and persistence of psoriatic plaques. The antithyroid thioureylenes, propylthiouracil and methimazole, are effective in the treatment of patients with psoriasis with a significant number of patients showing clearing or near clearing of their lesions after a several weeks of treatment. Methods: The present study examined the effect of treatment with propylthiouracil, given in a dose of 100 mg every 8 hours for 3 months, on the serum levels of TNF-alpha in 9 patients with plaque psoriasis. Results: Propylthiouracil therapy did not result in a significant decline in serum TNF-alpha concentrations. Conclusions: The findings suggest that the therapeutic effect of propylthiouracil in psoriasis appears not to be related to any change in the concentration of TNF-alpha but occurs via an anti-proliferative mechanism as we have previously speculated. |
Databáze: | MEDLINE |
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