| Autor: |
Ghantous HN; Department of Anesthesiology, College of Medicine, University of Arizona, Tucson 85724., Fernando J, Gandolfi AJ, Brendel K |
| Jazyk: |
angličtina |
| Zdroj: |
Anesthesia and analgesia [Anesth Analg] 1992 Sep; Vol. 75 (3), pp. 436-40. |
| DOI: |
10.1213/00000539-199209000-00021 |
| Abstrakt: |
Guinea pig liver slices were used to evaluate the biotransformation and hepatotoxic potential of sevoflurane. Precision-cut liver slices (250-300 microns thick) were incubated in sealed roller vials in buffer at 37 degrees C under 95% O2. Sevoflurane was added to produce 0.9 or 2.1 mM medium concentrations. After incubation (6-24 h), the intracellular K+ content and protein synthesis were determined, along with the defluorination of sevoflurane. Isoflurane was included for comparative purposes. Sevoflurane (2.1 mM) and isoflurane (2.3 mM) had no effect on slice K+ content, but both anesthetics depressed protein synthesis. The biotransformation of sevoflurane was maximal at 95% O2, with threefold more F- produced from sevoflurane than isoflurane. Sevoflurane appears to have a minimal effect on the guinea pig liver slices, which is consistent with in vivo studies in which minimal or no hepatotoxicity has been observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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