| Autor: |
Shirinian EA; Laboratory of Pharmacology of Cardiovascular Drugs, Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Azatutyan pr. 26, Yerevan, 375014 Armenia., Arutiunian SA, Petrosian AA, Gevorkian GA, Markarian EA, Vartanian SO, Medvedev OS, Garibdzhanian BT |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2004 Jan-Feb; Vol. 67 (1), pp. 11-4. |
| Abstrakt: |
In rats with a hemodynamic disorder caused by acute myocardial ischemia, preliminary administration of beditin in a dose of 25 mg/kg fully prevents a manifold increase in the level of 45Ca2+ in the cytosol of brain cells and leads to enhanced trapping and accumulation of labeled calcium in endoplasmic reticulum. With respect to calcium binding in endoplasmic reticulum, the action of beditin substantially differs from that of verapamil. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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