| Autor: |
Barriault L; Department of Chemistry, 10 Marie Curie, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5. lbarriau@science.uottawa.ca, Ang PJ, Lavigne RM |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2004 Apr 15; Vol. 6 (8), pp. 1317-9. |
| DOI: |
10.1021/ol049680r |
| Abstrakt: |
The first synthesis of the tricyclic core of Penostatin F (1) using a stereocontrolled Diels-Alder reaction and a Claisen rearrangement in succession has been achieved in nine steps from commercially available methyl acetoacetate and (E)-2-decenal. Penostatin F is a metabolite isolated from a fungal strain of Penicillium sp., OUPS-79, separated from the marine alga Enteromorphia intestinalis and exhibits significant cytotoxicity against cultured P388 Leukemia cells (ED(50) = 1.4 micromol/mL). [reaction: see text] |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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