Dietary fat regulates mammary stearoyl coA desaturase expression and activity in lactating mice.

Autor: Singh K; AgResearch, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand. kuljeet.singh@agresearch.co.nz, Hartley DG, McFadden TB, Mackenzie DD
Jazyk: angličtina
Zdroj: The Journal of dairy research [J Dairy Res] 2004 Feb; Vol. 71 (1), pp. 1-6.
DOI: 10.1017/s0022029903006502
Abstrakt: Mice in mid lactation (n=6 per group) were fed a control diet (1.19% fat), or diets containing safflower oil (25% w/w) or olive oil (25% w/w) for 7d. Mammary and liver stearoyl CoA desaturase (SCD) mRNA levels and mammary SCD activities were higher in lactating mice fed the control diet than in those fed the oil-supplemented diets. Further, mammary SCD mRNA was directly related to mammary SCD activity. Milk fat composition was influenced by dietary fat composition. The olive oil diet, high in 18:1, led to high levels of this fatty acid in milk and the safflower oil diet, high in 18:2, resulted in a milk fat with high levels of 18:2. These results show that there is regulation of SCD at the transcriptional level, associated with changes in enzyme activity and in milk fat composition.
Databáze: MEDLINE