Androgen receptor protein expression in prostatic tissues in Black and Caucasian men.

Autor: Olapade-Olaopa EO; Department of Urology, Leicester General Hospital, Leicester, United Kingdom. okeoffa@yahoo.com, Muronda CA, MacKay EH, Danso AP, Sandhu DP, Terry TR, Habib FK
Jazyk: angličtina
Zdroj: The Prostate [Prostate] 2004 Jun 01; Vol. 59 (4), pp. 460-8.
DOI: 10.1002/pros.20014
Abstrakt: Background: CaP has a higher incidence and mortality in Black men. We hypothesized that subpopulation differences in AR expression may contribute to this phenomenon.
Method: AR immunostaining was compared in epithelium and PES of normal, BPH, and CaP tissues from Black African men and UK Caucasian men.
Results: AR expression was similar in normal prostatic epithelium of both groups, but was higher in BPH and CaP epithelium of Black than Caucasian men (P Conclusions: Variations in AR expression between subpopulations may contribute to the phenotypic differences of prostatic diseases in Black and Caucasian men.
(Copyright 2004 Wiley-Liss, Inc.)
Databáze: MEDLINE
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