| Autor: |
Gandy S; Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA. samgandy@earthlink.net, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET |
| Jazyk: |
angličtina |
| Zdroj: |
Mechanisms of ageing and development [Mech Ageing Dev] 2004 Feb; Vol. 125 (2), pp. 149-51. |
| DOI: |
10.1016/j.mad.2003.12.002 |
| Abstrakt: |
Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). Immunized monkeys developed anti-Abeta titers exceeding 1:1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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