| Autor: |
Wong N; Department of Biochemistry, Faculty of Medicine, University of Hong Kong, Hong Kong. nswong@hkucc.hku.hk, Diao CT, Wong T |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2003 Dec; Vol. 1010, pp. 358-60. |
| DOI: |
10.1196/annals.1299.066 |
| Abstrakt: |
Opioid receptors are G-protein-coupled cell-surface receptors that are mainly expressed in neuronal cells. Stimulation of the kappa-opioid receptor expressed by cultured human epithelial cancer cells promotes staurosporine-induced apoptosis. In this study, while Bcl-2 did not inhibit staurosporine-induced apoptosis, it did inhibit the kappa-opioid receptor-mediated potentiation of apoptosis. The results suggest that Bcl-2 targets a step that is specific to the signaling pathway of the kappa-opioid receptor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text