| Autor: |
Beltrametti F; Vicuron Pharmaceuticals Italy S.r.l., Via R. Lepetit, 34, 21040, Gerenzano (Varese) Italy. fbeltrametti@ricuron.it, Jovetic S, Feroggio M, Gastaldo L, Selva E, Marinelli F |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 2004 Jan; Vol. 57 (1), pp. 37-44. |
| DOI: |
10.7164/antibiotics.57.37 |
| Abstrakt: |
In actinomycetes the catabolism products of branched chain amino acids provide biosynthetic precursors for the formation of several lipid-containing antibiotics. We have determined in Nonomuraea sp. ATCC 39727 the effect of valine on production of glycopeptide antibiotic A40926, which is a complex of factors structurally differing in fatty acid moieties. Addition of valine to minimal medium increased A40926 production and modified complex composition towards a mono-component. Similar results were also obtained in a rich production medium. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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