| Autor: |
Gomes MS; Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal. sgomes@ibmc.up.pt, Flórido M, Cordeiro JV, Teixeira CM, Takeuchi O, Akira S, Appelberg R |
| Jazyk: |
angličtina |
| Zdroj: |
Immunology [Immunology] 2004 Feb; Vol. 111 (2), pp. 179-85. |
| DOI: |
10.1111/j.0019-2805.2003.01807.x |
| Abstrakt: |
The role of the Toll-like receptor (TLR)-2 in the generation of protective immunity to Mycobacterium avium was evaluated using gene-disrupted mice. TLR-2-/- mice were more susceptible than wild-type C57Bl/6 mice to M. avium strains that were able to proliferate in vivo before the development of protective immunity and mycobacteriostasis. In contrast, the elimination of non-virulent strains was not affected by the mutation. The generation of interferon-gamma (IFN-gamma)-producing T cells and the expression of the interleukin-12 p40 gene were reduced in TLR-2-deficient mice as compared to C57Bl/6 mice early during infection with M. avium strain 2447. The generation of protective CD4+ T cells was also compromised in the mutated mice as compared with the controls. Our data show that TLR-2 is required for optimal immunity against certain virulent M. avium strains. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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