| Autor: |
Flórido M; Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal., Gonçalves AS, Gomes MS, Appelberg R |
| Jazyk: |
angličtina |
| Zdroj: |
Immunology [Immunology] 2004 Mar; Vol. 111 (3), pp. 323-7. |
| DOI: |
10.1111/j.1365-2567.2004.01812.x |
| Abstrakt: |
C57Bl/6 mice and mice deficient in the CD40 molecule were infected with three strains of Mycobacterium avium. Two of the M. avium strains proliferated more extensively in CD40-deficient (CD40-/-) mice than in control mice. The increased susceptibility to infection of CD40-/- mice was associated with the generation of poorer interleukin-12 (IL-12) p40 and interferon-gamma (IFN-gamma) responses as compared to the controls, suggesting a role for CD40 in the development of protective immunity. In contrast, direct triggering of CD40 on infected macrophages failed to induce any anti-mycobacterial activity in infected macrophages. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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