| Autor: |
Yang X; Gastroenterology Unit, University of Oxford, Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK., Ahmad T, Gogus F, Verity D, Wallace GR, Madanat W, Kanawati CA, Stanford MR, Fortune F, Jewell DP, Marshall SE |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics [Eur J Immunogenet] 2004 Feb; Vol. 31 (1), pp. 11-4. |
| DOI: |
10.1111/j.1365-2370.2004.00444.x |
| Abstrakt: |
Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Delta32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behçet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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