| Autor: |
Krzek J; Department of Inorganic and Analytical Chemistry, Collegium Medicum of the Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland. jankrzek@cm-uj.krakow.pl, Czekaj JS, Rzeszutko W |
| Jazyk: |
angličtina |
| Zdroj: |
Acta poloniae pharmaceutica [Acta Pol Pharm] 2003 Sep-Oct; Vol. 60 (5), pp. 343-9. |
| Abstrakt: |
The conditions for the identification and quantitative determination of menthol and methyl salicylate in ointment Balsamum Mentholi Compositum on a hydrocarbon-ester base (vaseline-lanolin), have been established by using capillary gas chromatography with cool on-column injection and flame ionization detection (FID). The good separation of menthol (tR = 7.2 min), methyl salicylate (tR = 8.7 min) and thymol (tR = 12.3 min) and camphor (tR = 6.0 min), used as alternative internal standards, beside vehiculum constituents (peak of tR = 15.8 min) was obtained. The method features a high sensitivity - detection limit for menthol and methyl salicylate was 0.1 ng and 5.0 ng, respectively, high accuracy, precision and recovery for active substances: 100.0% +/- 2.2%, when camphor was used as an internal standard. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
