| Autor: |
Sonnenfeld G; Dept. de Bioquimica & Instituto de Investigaciones Biomedicas 'Alberto Sols', UAM-CSIC, Madrid, Spain., Aviles H, Belay T, Vance M, Fountain K |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology [J Gravit Physiol] 2002 Jul; Vol. 9 (1), pp. P199-200. |
| Abstrakt: |
Immune function is altered in stressful situations, including space flight. This may result in increased risk of infection. Antiorthostatic suspension has been used to study the effects of space flight-like conditions on immunity. The mechanisms of promoting infection in stressful situations have not been defined, but catecholamines could play a role. In the present study gram negative bacteria grown with catecholamines showed enhanced bacterial growth compared to controls. Additionally, antiorthostatically suspended mice infected with Klebsiella pneumoniae showed decreased survival compared to restrained or normally caged controls. Therefore, stress-induced enhanced bacterial growth and immunosuppression could play a role in suspension-induced enhanced mortality due to infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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