| Autor: |
Wang NZ; Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA., Urry DW, Swaim SF, Gillette RL, Hoffman CE, Hinkle SH, Coolman SL, Luan CX, Xu J, Kemppainen BW |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2004 Feb; Vol. 27 (1), pp. 37-43. |
| DOI: |
10.1046/j.0140-7783.2003.00544.x |
| Abstrakt: |
Elevated thromboxane levels are associated with a number of disease states, including dermal pressure ulcers. When dazmegrel was orally administered to greyhound dogs wearing leg casts, it resulted in a sparring effect on the skin areas of potential pressure ulcer development. The objective of this research was to determine if bioelastic matrices could provide controlled release of thromboxane A2 synthetase inhibitor (dazmegrel) at tissue concentrations sufficient for inhibition of thromboxane synthesis. The animal used for these studies was the greyhound, which has thin skin, angular conformation, limited body fat and is predisposed to pressure ulcers similar to those occurring in humans. In vivo skin penetration studies showed that epidermal exposure to bioelastic thromboxane synthetase inhibitor (TSI) matrix resulted in local tissue concentrations of TSI sufficient for thromboxane synthetase inhibition. There were no significant differences between dazmegrel in the skin layers (epidermis, dermis and subcutaneous layers) on 1, 7 and 14-day exposures. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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