| Autor: |
Watanabe N; Department of Immunology, DNAX Research Institute, Palo Alto, California 94304-1104, USA., Hanabuchi S, Soumelis V, Yuan W, Ho S, de Waal Malefyt R, Liu YJ |
| Jazyk: |
angličtina |
| Zdroj: |
Nature immunology [Nat Immunol] 2004 Apr; Vol. 5 (4), pp. 426-34. Date of Electronic Publication: 2004 Feb 29. |
| DOI: |
10.1038/ni1048 |
| Abstrakt: |
T cell homeostasis is a self-regulating process for maintaining the size of the peripheral T cell pool. Although dendritic cells (DCs) seem to be important in T cell homeostasis, the molecular regulation of DC-mediated T cell homeostasis is unknown. We show that human DCs activated by thymic stromal lymphopoietin (TSLP) induced a robust expansion of autologous CD4(+) T cell populations, which depended on self peptide-major histocompatibility complex. The proliferating T cells adopted and maintained a central memory polyclonal phenotype and could differentiate into T helper type 1 or type 2 effector cells. These results, together with findings of TSLP expression in epithelial cells of mucosal lymphoid tissues and thymus, indicate that TSLP is involved in DC-mediated CD4(+) T cell homeostasis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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