| Autor: |
Schlosser KM; Department of Chemistry, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA., Krasutsky AP, Hamilton HW, Reed JE, Sexton K |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2004 Mar 04; Vol. 6 (5), pp. 819-21. |
| DOI: |
10.1021/ol049956v |
| Abstrakt: |
A highly efficient one-pot procedure for 3-sulfenylation of 2-carboxyindoles is described. Treatment of thiols with N-chlorosuccinimide at -78 degrees C in CH(2)Cl(2) affords sulfenyl chlorides in situ that readily react with 2-carboxyindoles to give 3-thioindoles in high yields. This new method is milder, produces less waste, and is compatible with a wide range of thiol and indole functionality. [reaction: see text] |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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