| Autor: |
Ngo TH; Department of Physiological Science, University of California-Los Angeles, Los Angeles, CA 90095, USA., Barnard RJ, Anton T, Tran C, Elashoff D, Heber D, Freedland SJ, Aronson WJ |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer research [Cancer Res] 2004 Feb 15; Vol. 64 (4), pp. 1252-4. |
| DOI: |
10.1158/0008-5472.can-03-3830 |
| Abstrakt: |
An isocaloric low-fat diet has been shown to slow androgen-sensitive Los Angeles Prostate Cancer-4 (LAPC-4) tumor growth in a mouse xenograft model. LAPC-4 cells were injected into male severe combined immunodeficient mice. After palpable tumors developed, the mice were divided into three groups, high-fat intact, high-fat castration, and low-fat castration. Tumor latency (18 versus 9 weeks; P < 0.001) and mouse survival (20.8 +/- 1.3 versus 13 +/- 0.7 weeks; P < 0.01) were significantly longer in the low-fat castration versus high-fat castration group. Reduced dietary fat intake delayed conversion from androgen-sensitive to -insensitive prostate cancer and significantly prolonged survival of severe combined immunodeficient mice bearing LAPC-4 xenografts. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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