| Autor: |
Badzhinian SA; Research Centre of Radiation Medicine and Burns, Ministry of Health, Republic of Armenia, Yerevan, 37508 Armenia. bsergei@web.am, Malakian MG, Arakelian VB, Kazarian SA, Grigorian DS, Badirian VA, Egiazarian DE |
| Jazyk: |
ruština |
| Zdroj: |
Radiatsionnaia biologiia, radioecologiia [Radiats Biol Radioecol] 2003 Nov-Dec; Vol. 43 (6), pp. 654-7. |
| Abstrakt: |
The presentation summarizes the results of studies on radioprotective activity of newly synthesized Mn(II) chelate with ethyl ester of salicylydene D,L-tyrosine, basing on the evaluation of its membrane-protective effects, revealed at different periods post the exposure of the organism to ionizing radiation. It was revealed that the administration of the compound into the animal organism before the radiation exposure (gamma-irradiation of 60Co at a dose level of 4.8 Gy) produced correcting action on structure-functional properties of erythrocyte membrane of irradiated rats: the excessive activation of lipid peroxidation of erythrocyte membranes was inhibited, the passive permeability of erythrocytes for K+ ions was normalized, the deformity and membrane potential of erythrocytes according to hydrogen-chlorine gradient were recovered. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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