| Autor: |
Crisóstomo FR; Instituto Universitario de Bio-Orgánica 'Antonio González', Universidad de La Laguna,C/Astrofísico Francisco Sánchez, 2, 38206 La Laguna, Tenerife, Spain., Martín T, Martín VS |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2004 Feb 19; Vol. 6 (4), pp. 565-8. |
| DOI: |
10.1021/ol0363570 |
| Abstrakt: |
[reaction: see text] The intramolecular nucleophilic attack of the epoxides on the exo-Co(2)(CO)(6)-propargylic cations provided cyclic ethers in good yields. The use of substrates with stereochemically defined oxiranes provided polysubstituted tetrahydropyrans and oxepanes with a high degree of stereocontrol. The cyclization is sensitive to the nature of the protecting group used at the primary alcohol, the use of tert-butyl carbonates being highly effective in terms of regioselectivity and yields. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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