| Autor: |
Widman M, Nordqvist M, Dollery CT, Briant RH |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 1975 Nov; Vol. 27 (11), pp. 842-8. |
| DOI: |
10.1111/j.2042-7158.1975.tb10227.x |
| Abstrakt: |
The metabolism of (-)-delta1-tetrahydrocannabinol (delta1-THC) has been studied in the isolated perfused dog lung. After intravascular administration of [3H]-delta1-THC there was an overall biotransformation of 12%. Two major metabolites were isolated and identified as 3'-hydroxy-delta1-THC and 4'-hydroxy-delta1-THC. 7-Hydroxy-delta1-THC was also present together with small amounts of 6alpha-hydroxy-delta1-THC and 6beta-hydroxy-delta1-THC. An in vitro experiment using a dog liver microsomal preparation was also carried out and showed that the major metabolites were 6beta-hydroxy-delta1-THC and 6alpha-hydroxy-delta1-THC. 7-Hydroxy-delta1-THC and 1,2-epoxy-hexahydrocannabinol were also isolated together with small amounts of 3'-hydroxy-delta1-THC and 4'-hydroxy-delta1-THC. The side-chain hydroxylated compounds are hitherto undescribed metabolites of delta1-THC. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text