| Autor: |
Sokol'nikov AA, Shinkevich TE, Kodentsova VN, Vrzhesinskaia OA, Spirichev VB |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy meditsinskoi khimii [Vopr Med Khim] 1992 Sep-Oct; Vol. 38 (5), pp. 15-7. |
| Abstrakt: |
Content of cytochromes b5 and P-450 as well as activity of soluble menadione reductase were estimated in liver microsomes of rats deprived of vitamin K or maintained both on a diet containing excess of vicasol or antivitamin K-pelentan. Deficiency of vitamin K led to an increase in the specific activity of menadione reductase and in content of the cytochrome P-450. Administration of antivitamin K did not alter these parameters but caused an increase in the content of cytochrome b5, which was not changed in vitamin K deficiency. Dissimilar effects of alimentary deficiency in vitamin K and of pelentan administration suggest that administration of antivitamins K (although it allowed to discover alterations developed via the system of vitamin K-dependent carboxylation) could not be completely identified with alimentary vitamin K deficiency. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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