| Autor: |
Gaĭnutdinov MKh, Konov VV, Ishmukhamedov RN, Zakharova TN, Khalilova MA, Safarov KS |
| Jazyk: |
ruština |
| Zdroj: |
Biokhimiia (Moscow, Russia) [Biokhimiia] 1992 Nov; Vol. 57 (11), pp. 1618-26. |
| Abstrakt: |
Studies of swelling of rat liver mitochondria in isoosmotic solutions of nonelectrolytes in the presence of respiration inhibitors revealed that submicromolar concentrations of Ca2+ increase the diameter of pores in the inner mitochondrial membrane--from 5.5-6.0 A (10(-8) M Ca2+) up to 7.5 A (3 x 10(-7) M Ca2+) and 8.0-8.5 A (6 x 10(-7) M Ca2+); these increases are prevented by cyclosporin A. The inner mitochondrial membrane with an effective pore diameter of 7.5 A is readily permeable for potassium but not for sodium ions, although with an increase in the effective pore diameter up to 8.0-8.5 A the selectivity of the K(+)-Na+ channel decreases. A conclusion is drawn that in the presence of submicromolar concentrations of Ca2+ the conductivity of the cyclosporin-sensitive pore for monovalent cations increases in the following order: K > Na > Li. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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