Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor.
| Autor: | Zablocki JA; Department of Medicinal Chemistry, Searle Research & Development, Skokie, Illinois 60077., Miyano M, Rao SN, Panzer-Knodle S, Nicholson N, Feigen L |
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| Jazyk: | angličtina |
| Zdroj: | Journal of medicinal chemistry [J Med Chem] 1992 Dec 25; Vol. 35 (26), pp. 4914-7. |
| DOI: | 10.1021/jm00104a019 |
| Databáze: | MEDLINE |
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