Efficacy and safety of calcipotriol (MC 903) ointment in psoriasis vulgaris. A randomized, double-blind, right/left comparative, vehicle-controlled study.

3.94). Local side effects were equally common with calcipotriol and placebo. The mean serum calcium remained unchanged.
Conclusion: Topical application of up to 50 gm of calcipotriol ointment per week was found to be an effective and safe treatment of psoriasis vulgaris. -->
Substance Nomenclature: 0 (Dermatologic Agents)
0 (Ointments)
143NQ3779B (calcipotriene)
FXC9231JVH (Calcitriol)
Entry Date(s): Date Created: 19921201 Date Completed: 19930208 Latest Revision: 20190709
Update Code: 20231215
DOI: 10.1016/0190-9622(92)70299-u
PMID: 1479106
Autor: Dubertret L; Department of Dermatology, University Hospital of Saint-Louis, Paris, France., Wallach D, Souteyrand P, Perussel M, Kalis B, Meynadier J, Chevrant-Breton J, Beylot C, Bazex JA, Jurgensen HJ
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 1992 Dec; Vol. 27 (6 Pt 1), pp. 983-8.
DOI: 10.1016/0190-9622(92)70299-u
Abstrakt: Background: The biologically active form of vitamin D3, calcitriol, may offer a new therapeutic approach to psoriasis. Calcipotriol, a new vitamin D3 analogue, is at least 100 times less calcemic than calcitriol.
Objective: Our purpose was to study the efficacy and safety of calcipotriol in the treatment of psoriasis vulgaris.
Methods: In a right/left comparative, double-blind study, treatment with calcipotriol ointment (50 micrograms/gm) twice daily and placebo was given for 4 weeks. The preferred treatment was continued, without opening the code, for another 4 weeks. Efficacy, as measured by the Psoriasis Area and Severity Index and by the investigator's and patient's global assessment, and safety were assessed every 2 weeks.
Results: The mean Psoriasis Area and Severity Index fell in 4 weeks from 14.2 to 6.3 with calcipotriol and from 14.1 to 9.2 with placebo (p < 0.001; 95% confidence interval for difference: 1.78-->3.94). Local side effects were equally common with calcipotriol and placebo. The mean serum calcium remained unchanged.
Conclusion: Topical application of up to 50 gm of calcipotriol ointment per week was found to be an effective and safe treatment of psoriasis vulgaris.
Databáze: MEDLINE
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