| Autor: |
Bergkamp FJ; MEDIAL Medical Diagnostic Laboratories, Kennemer Gasthuis, Boerhaavelaan 22, 2035 RC Haarlem, the Netherlands. fbergkam@kg.nl, van Berkel AM, van der Linden PW, Gorgels JP |
| Jazyk: |
angličtina |
| Zdroj: |
The Netherlands journal of medicine [Neth J Med] 2003 Nov; Vol. 61 (11), pp. 371-5. |
| Abstrakt: |
Although hypercalcaemia is often encountered during the course of malignant disease, hypocalcaemia appears to be rather rare. We describe a 37-year-old patient with metastatic carcinoma of the breast, who developed extreme hypocalcaemia (as low as 0.75 mmol calcium per litre) after chemotherapy. This is caused by a combination of hungry-bone syndrome and an insufficient parathyroid response. The latter may be the result of a direct toxic effect of chemotherapy on parathyroid hormone (PTH) synthesis possibly in combination with microscopic tumour infiltration in the parathyroid glands. Correction of the extreme hypocalcaemia over a period of 100 days by oral and intravenous calcium supplementation, corresponding to a total of 352 gram elemental calcium (1/3 of the total body calcium), resulted in gradual symptomatic relief. The possible mechanisms for these findings are discussed and the literature is briefly reviewed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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