Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid.

Autor: Krueger WA; Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, 72076 Tübingen, Germany. wolfgang.krueger@uni-tuebingen.de, Kottler B, Will BE, Heininger A, Guggenberger H, Unertl KE
Jazyk: angličtina
Zdroj: Journal of clinical microbiology [J Clin Microbiol] 2004 Feb; Vol. 42 (2), pp. 929-32.
DOI: 10.1128/JCM.42.2.929-932.2004
Abstrakt: Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid.
Databáze: MEDLINE