Prevalence of antinuclear autoantibodies in the serum of normal blood dornors.
| Autor: | Fernandez SA; Department of Dermatology, Immunopathology Laboratory, Hospital das Cl nicas, University of S o Paulo, S o Paulo, SP, Brazil., Lobo AZ, Oliveira ZN, Fukumori LM, P rigo AM, Rivitti EA |
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| Jazyk: | angličtina |
| Zdroj: | Revista do Hospital das Clinicas [Rev Hosp Clin Fac Med Sao Paulo] 2003 Nov-Dec; Vol. 58 (6), pp. 315-9. Date of Electronic Publication: 2004 Jan 28. |
| DOI: | 10.1590/s0041-87812003000600005 |
| Abstrakt: | Objective: To examine the presence of serum antinuclear autoantibodies in a healthy population. Methods: Serum of 500 normal blood donors between 18 and 60 years of age were tested for the presence of autoantibodies. Antinuclear antibodies were detected by indirect immunofluorescence technique using HEp-2 epithelial cells as the substrate. The presence of dnaN was detected by indirect immunofluorescence technique using Critidia lucillae as the substrate. Anti-SSA (RO), anti-SSB (LA), anti-Sm, and anti-RNP were determined by double radial immunodiffusion. Results: In the evaluation of the presence of serum antibodies, antinuclear antibodies were detected in 22.6% of the sera. The presence of other antibodies was not significant. The majority of the titers were 1:40. Conclusion: The presence of autoantibodies is not necessarily pathologic and has to be related to the age group, gender, and clinical condition of the patient. |
| Databáze: | MEDLINE |
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