[Alterations of inotropic function of isolated heart and extent of injury of cardiomyocytes after cannabinoid receptor activation during ischemia and reperfusion].

Autor: Maslov LN; Tomsk State Pedagogical University, Russia., Lasukova OV, Krylatov AV, Lishmanov IuB, Pertwee R
Jazyk: ruština
Zdroj: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2003 Sep; Vol. 89 (9), pp. 1108-16.
Abstrakt: It was found that CB1- and CB2-receptor activation by intravenous administration of the selective CB-agonist HU-210 at a dose 0.1 mg/kg prompts an increase of myocardial resistance to the pathogenic action of ischemia and reperfusion in vitro. The revealed effects of HU-210 do not depend on the activation of CB-receptors in the myocardium.
Databáze: MEDLINE