The death of articular chondrocytes after intra-articular fracture in humans.
| Autor: | Murray MM; Department of Orthopadic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. mmmurray@partners.org, Zurakowski D, Vrahas MS |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of trauma [J Trauma] 2004 Jan; Vol. 56 (1), pp. 128-31. |
| DOI: | 10.1097/01.TA.0000051934.96670.37 |
| Abstrakt: | Background: In this study, we wished to determine whether chondrocyte death occurs after intra-articular fracture and might thus contribute to the development of posttraumatic arthritis. Methods: Articular fracture fragments were obtained from 30 patients and the terminal deoxynucleotide transferase-mediated dUTP nick-end labeling assay was used to identify dead or dying cells. Results: Dead or dying cells were identified in all fracture fragments, with an average rate of cell death of 35%. Rates of cell death greater than 90% were seen in 4 of the 30 specimens studied. Conclusion: Although rates of apoptosis in osteoarthritis have been reported to average 15%, the rate in this fracture population was more than twice this value (35%). The high rate of cell death noted here may help explain the occurrence of posttraumatic arthritis even in anatomically fixed intra-articular fractures. |
| Databáze: | MEDLINE |
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