| Autor: |
Barykina OP; St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch, Russian Academy of Medical Sciences, 3, Dinamo Prospect, 197110, St. Petersburg, Russia., Iuzhakov VV, Chalisova NI, Kvetnoĭ IM, Konovalov SS |
| Jazyk: |
ruština |
| Zdroj: |
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2003; Vol. 12, pp. 128-31. |
| Abstrakt: |
The experiments were performed in mice with transplanted Lewis lung carcinoma. The injections of synthetic peptide vilon at the doses 1 mg/kg significantly increased the survival of mice. So vilon has possessed the oncomodulating action on the transplanted carcinoma. The synchronous injection both of vilon and cyclophosphan at the doses 100 mg/kg decreases the survival of mice. There was also studied in spleen organotypic tissue culture the effect of vilon and cyclophosphan on the development of explants of rats of various age: 1 day and 2 years old. Vilon stimulated apoptosis both in young and old rats, but the inhibitory effect of cyclophosphan was abolished in the presence of vilon in culture media at the dose 5 ng/ml. The results obtained suggested that perspective preparates in the cancer therapy--vilon and cytostatic drugs-, must be used not synchronously. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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