| Autor: |
Ninfa EG; Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA., Dixon JE |
| Jazyk: |
angličtina |
| Zdroj: |
Trends in cell biology [Trends Cell Biol] 1994 Dec; Vol. 4 (12), pp. 427-30. |
| DOI: |
10.1016/0962-8924(94)90103-1 |
| Abstrakt: |
Given the importance of tyrosine phosphorylation of proteins in signalling pathways, it is perhaps not surprising that protein tyrosine phosphatases (PTPs) are involved in the pathogenesis of certain human diseases. A PTP produced by the Yersinia bacteria (which can cause bubonic plague, septicemia and enteric diseases) is thought to be used as a 'weapon' against host cell functions. In addition, dysfunction of cells' endogenous PTPs may contribute to defective immune function, to cancer and to diabetes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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