[Methionine sulfoximine and phosphinothricin--glutamine synthetase inhibitors and activators and their herbicidal activity (A review)].

Autor: Evstigneeva ZG; Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071 Russia., Solov'eva NA, Sidel'nikova LI
Jazyk: ruština
Zdroj: Prikladnaia biokhimiia i mikrobiologiia [Prikl Biokhim Mikrobiol] 2003 Nov-Dec; Vol. 39 (6), pp. 613-8.
Abstrakt: Derivatives of methionine sulfoximine (MSO) and phosphinothrycin (PPT), which are analogues of glutamate, exhibit selective herbicidal activity. This effect is accounted for by impairments of nitrogen metabolism, resulting from inhibition of its key enzyme in plants, glutamine synthetase (EC 6.3.1.2). Inhibition of the enzyme causes ammoniac nitrogen to accumulate and terminates the synthesis of glutamine. Changes in the content of these two metabolites (excess ammonium and glutamine deficiency) act in a concert to cause plant death. However, low concentrations of MSO, PPT, and their metabolites produce an opposite effect: glutamine synthetase is activated, with concomitant stimulation of plant growth and productivity. The mechanisms whereby MSO and PPT affect glutamine synthetase activity are discussed in the context of nitrogen metabolism in plants.
Databáze: MEDLINE