[Free radicals in mercury-resistant bacteria indicate a novel metabolic pathway].

6)-alpha-D-Glcp-(1-->1)-alpha-D-Glcp, or, in other words, as 6-O-(2-deoxy-2-[N-methyl]hydroxylamino-beta-D- glucopyranosyl)-alpha-alpha-trehalose, previously discovered in Micrococcus luteus (lysodeikticus) and named lysodektose. The compound is suggested to be a novel intermediate of a previously unknown basic metabolic pathway of trehalose transformation in bacteria, a potential target for antibacterial drug development. -->
Substance Nomenclature: 0 (Free Radicals)
0 (Trisaccharides)
126077-90-5 (lysodektose)
B8WCK70T7I (Trehalose)
FXS1BY2PGL (Mercury)
Entry Date(s): Date Created: 20031219 Date Completed: 20040402 Latest Revision: 20131121
Update Code: 20231215
PMID: 14679895
Autor: Ostrovskiĭ DN; Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 117071 Russia. ost@inbi.ras.ru, Demina GR, Biniukov VI, Shashkov AS, Schloter M
Jazyk: ruština
Zdroj: Mikrobiologiia [Mikrobiologiia] 2003 Sep-Oct; Vol. 72 (5), pp. 594-9.
Abstrakt: A mercury resistant-soil bacterium P.10.15, identified as a close relative of Pseudomonas veronii, was shown to accumulate a specific compound in the stationary phase of growth. This compound is converted to a long-lived free radical under oxidizing conditions, as registered by its EPR signal at room temperature. The compound was purified by ion-exchange and gel-filtration chromatography and identified by mass spectroscopy, 2D NMR, and EPR as a trisaccharide beta-D-GlcpNOH,CH3-(1-->6)-alpha-D-Glcp-(1-->1)-alpha-D-Glcp, or, in other words, as 6-O-(2-deoxy-2-[N-methyl]hydroxylamino-beta-D- glucopyranosyl)-alpha-alpha-trehalose, previously discovered in Micrococcus luteus (lysodeikticus) and named lysodektose. The compound is suggested to be a novel intermediate of a previously unknown basic metabolic pathway of trehalose transformation in bacteria, a potential target for antibacterial drug development.
Databáze: MEDLINE
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