| Autor: |
Döffinger R; Department of Clinical Immunology and Biochemistry, Addenbrooke's Hospital, Cambridge, United Kingdom. rd270@cam.ac.uk, Helbert MR, Barcenas-Morales G, Yang K, Dupuis S, Ceron-Gutierrez L, Espitia-Pinzon C, Barnes N, Bothamley G, Casanova JL, Longhurst HJ, Kumararatne DS |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2004 Jan 01; Vol. 38 (1), pp. e10-4. Date of Electronic Publication: 2003 Dec 04. |
| DOI: |
10.1086/380453 |
| Abstrakt: |
We evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody to interferon-gamma (IFN-gamma) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-gamma can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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