[Tumoral markers and acute-phase reactants in the diagnosis of pancreatic cancer].

Autor:	Irigoyen Oyarzabal AM; Servicio de Gastroenterología. Hospital de Cruces. Baracaldo. Vizcaya. Spain. airigoyen@hcru.osakidetza.net, Amiguet García JA, López Vivanco G, Genollá Subirats J, Muñoz Villafranca MC, Ojembarrena Martínez E, Liso Irurzun P
Jazyk:	Spanish; Castilian
Zdroj:	Gastroenterologia y hepatologia [Gastroenterol Hepatol] 2003 Dec; Vol. 26 (10), pp. 624-9.
DOI:	10.1016/s0210-5705(03)70421-x
Abstrakt:	Objective: To analyze the diagnostic accuracy of the following parameters in the diagnosis of pancreatic cancer: carcinoembryonic antigen (CEA), tissue plasminogen activator (TPA), carbohydrate antigen 19-9 (CA 19-9), carbohydrate antigen 50 (CA 50), alpha-1-antitrypsin (AAT), alpha-2 macroglobulin (AMG), and ceruloplasmin (CP). PATIENTS AND MENTOD: We prospectively studied 58 patients with pancreatic cancer, 40 with alcoholic pancreatitis and 40 healthy controls, in whom the above-mentioned parameters were analyzed. Receiver operating characteristic curves (ROC curves) were analyzed. Results: The specificity of TPA, CA 19-9 and CA 50 in the differential diagnosis between pancreatic cancer and chronic pancreatitis was 87.5%, 90% and 95% respectively, with a sensitivity of nearly 90%. Although levels of AAT, AMG and CP were higher in patients with cancer than in those with pancreatitis, their specificity was lower, approximately 65%. CEA and TPA showed a positive association with the presence of metastases. Conclusion: TPA, CA 19-9 and CA 50 were useful in the differential diagnosis between pancreatic cancer and chronic pancreatitis.
Databáze:	MEDLINE
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