Evaluation of the antimicrobial property of Polyalthia longifolia var. pendula: isolation of a lactone as the active antibacterial agent from the ethanol extract of the stem.

Autor: Faizi S; H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. shaheen@khi.comsats.net.pk, Mughal NR, Khan RA, Khan SA, Ahmad A, Bibi N, Ahmed SA
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2003 Dec; Vol. 17 (10), pp. 1177-81.
DOI: 10.1002/ptr.1333
Abstrakt: Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula stem, which showed promising antibacterial activity against thirteen Gram-positive and nine Gram-negative organisms, furnished (3S,4R)-3,4,5-trihydroxypentanoic acid-1,4-lactone (1) as the active principle. The structure of (1) was established by UV, IR, mass, 1H and 13C NMR as well as 2D NMR spectral studies and the formation of its acetate (1a). On acetylation activity of (1) was markedly reduced. It is synthetically well known and only recently isolated from two plants, however, its antimicrobial activity was not reported earlier. The extract, fractions and pure compounds did not show any remarkable activity against fungi and Mycobacterium fortuitum, and M. smegmatis.
(Copyright 2003 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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