| Autor: |
Vantomme V; Ludwig Institute for Cancer Research, 74 avenue Hippocrate, UCL 7459, B-1200 Brussels, Belgium., Boël P, De Plaen E, Boon T, van der Bruggen P |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer immunity [Cancer Immun] 2003 Dec 10; Vol. 3, pp. 17. Date of Electronic Publication: 2003 Dec 10. |
| Abstrakt: |
"Cancer-germline" genes such as those of the MAGE family are expressed in many tumors and in male germline cells, but are silent in normal tissues. They encode shared tumor-specific antigens, which have been used in therapeutic vaccination trials of cancer patients. MAGE-6 is expressed in more than 70% of metastatic melanomas and more than 50% of carcinomas of the lung, esophagus, bladder, and head and neck. We report here the identification of a new MAGE-6 antigenic peptide, which is recognized by a tumor-specific cytolytic T lymphocyte clone isolated from a melanoma patient. The peptide, ISGGPRISY, corresponds to positions 293 to 301 of the MAGE-6 protein sequence and is presented by HLA-Cw1601 molecules. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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