| Autor: |
Lee JK; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-8322, USA. jaeklee@virginia.edu, Bussey KJ, Gwadry FG, Reinhold W, Riddick G, Pelletier SL, Nishizuka S, Szakacs G, Annereau JP, Shankavaram U, Lababidi S, Smith LH, Gottesman MM, Weinstein JN |
| Jazyk: |
angličtina |
| Zdroj: |
Genome biology [Genome Biol] 2003; Vol. 4 (12), pp. R82. Date of Electronic Publication: 2003 Nov 25. |
| DOI: |
10.1186/gb-2003-4-12-r82 |
| Abstrakt: |
Microarray gene-expression profiles are generally validated one gene at a time by real-time RT-PCR. We describe here a different approach based on simultaneous mutual validation of large numbers of genes using two different expression-profiling platforms. The result described here for the NCI-60 cancer cell lines is a consensus set of genes that give similar profiles on spotted cDNA arrays and Affymetrix oligonucleotide chips. Global concordance is parameterized by a 'correlation of correlations' coefficient. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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